Generic Name: repaglinide (oral) (re PAG li nide)
Brand Names: Prandin
What is repaglinide?
Repaglinide is an oral diabetes medicine that helps control blood sugar levels. This medication lowers blood sugar by causing the pancreas to produce insulin.
Repaglinide is used together with diet and exercise to treat type 2 diabetes. Other diabetes medicines are sometimes used in combination with repaglinide if needed.
Repaglinide may also be used for purposes not listed in this medication guide.
What is the most important information I should know about repaglinide?
Do not use this medication if you are allergic to repaglinide, if you have type 1 diabetes, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). You should not use repaglinide together with gemfibrozil (Lopid) or NPH insulin (such as isophane insulin).
Take care not to let your blood sugar get too low. Low blood sugar (hypoglycemia) can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Other sugar sources include orange juice and milk. Be sure your family and close friends know how to help you in an emergency.
Also watch for signs of blood sugar that is too high (hyperglycemia). These symptoms include increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss. Your blood sugar will need to be checked often, and you may need to adjust your repaglinide dose.
Repaglinide is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.
What should I discuss with my doctor before taking repaglinide?
Do not use this medication if you are allergic to repaglinide, if you have type 1 diabetes, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). You should not use repaglinide together with gemfibrozil (Lopid) or NPH insulin (such as isophane insulin).
To make sure you can safely take repaglinide, tell your doctor if you have liver disease.
FDA pregnancy category C. It is not known whether repaglinide will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether repaglinide passes into breast milk or if it could be harmful to a nursing baby. You should not breast-feed while you are taking repaglinide.
How should I take repaglinide?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Repaglinide is usually taken 2 to 4 times daily, within 30 minutes before eating a meal. Follow your doctor's instructions. If you skip a meal, do not take your dose of repaglinide. Wait until your next meal.
Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. Visit your doctor regularly.
Know the signs of low blood sugar (hypoglycemia) and how to recognize them: headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating.
Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.
Also watch for signs of blood sugar that is too high (hyperglycemia). These symptoms include increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss.
Check your blood sugar carefully during a time of stress or illness, if you travel, exercise more than usual, drink alcohol, or skip meals. These things can affect your glucose levels and your dose needs may also change.
Your doctor may want you to stop taking repaglinide for a short time if you become ill, have a fever or infection, or if you have surgery or a medical emergency.
Ask your doctor how to adjust your repaglinide dose if needed. Do not change your medication dose or schedule without your doctor's advice.
Repaglinide is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.
Use repaglinide regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
Store repaglinide at room temperature away from moisture and heat.
See also: Prandin dosage (in more detail)
What happens if I miss a dose?
Take the missed dose as soon as you remember, but only if you are getting ready to eat a meal. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A repaglinide overdose can cause life-threatening hypoglycemia.
Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).
What should I avoid while taking repaglinide?
Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.
Repaglinide side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:
seizure (convulsions);
severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;
pale or yellowed skin, dark colored urine, fever, confusion or weakness; or
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash.
Less serious side effects may include:
runny or stuffy nose, sneezing, cough, cold or flu symptoms;
diarrhea, nausea;
back pain, headache;
dizziness;
blurred vision;
joint pain; or
temporary hair loss.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect repaglinide?
Tell your doctor about all other medications you use, especially:
cyclosporine (Gengraf, Neoral, Sandimmune);
St. John's wort;
an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), or telithromycin (Ketek);
an antifungal medication such as fluconazole (Diflucan), itraconazole (Sporanox), or ketoconazole (Nizoral);
a barbiturate such as phenobarbital (Solfoton);
heart or blood pressure medication such as diltiazem (Cartia, Cardizem), nicardipine (Cardene), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others;
HIV/AIDS medicine such as delavirdine (Rescriptor), efavirenz (Sustiva, Atripla), fosamprenavir (Lexiva), indinavir (Crixivan), ritonavir (Norvir), and others;
rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), or rifapentine (Priftin); or
seizure medication such as carbamazepine (Carbatrol, Equetro, Tegretol), phenytoin (Dilantin), primidone (Mysoline), and others.
You may be more likely to have hyperglycemia (high blood sugar) if you are taking repaglinide with other drugs that raise blood sugar, such as:
isoniazid;
diuretics (water pills);
steroids (prednisone and others);
phenothiazines (Compazine and others);
thyroid medicine (Synthroid and others);
birth control pills and other hormones;
seizure medicines (Dilantin and others); and
diet pills or medicines to treat asthma, colds or allergies.
You may be more likely to have hypoglycemia (low blood sugar) if you are taking other drugs that lower blood sugar, such as:
probenecid (Benemid);
some nonsteroidal anti-inflammatory drugs (NSAIDs);
aspirin or other salicylates (including Pepto-Bismol);
a blood thinner (warfarin, Coumadin, Jantoven, and others);
sulfa drugs (Bactrim, Septra, Sulfatrim, SMX-TMP, and others);
a monoamine oxidase inhibitor (MAOI); or
other oral diabetes medications, especially acarbose (Precose), metformin (Glucophage), miglitol (Glyset), pioglitazone (Actos, Duetact, Actoplus Met), or rosiglitazone (Avandia, Avandaryl, Avandamet).
These lists are not complete and there are many other medicines that can increase or decrease the effects of repaglinide on lowering your blood sugar. Using certain medicines can make it harder for you to tell when you have low blood sugar. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
More Prandin resources
- Prandin Side Effects (in more detail)
- Prandin Dosage
- Prandin Use in Pregnancy & Breastfeeding
- Drug Images
- Prandin Drug Interactions
- Prandin Support Group
- 5 Reviews for Prandin - Add your own review/rating
- Prandin Prescribing Information (FDA)
- Prandin Monograph (AHFS DI)
- Prandin Advanced Consumer (Micromedex) - Includes Dosage Information
- Prandin Consumer Overview
- Prandin MedFacts Consumer Leaflet (Wolters Kluwer)
- Repaglinide Professional Patient Advice (Wolters Kluwer)
Compare Prandin with other medications
- Diabetes, Type 2
Where can I get more information?
- Your pharmacist can provide more information about repaglinide.
See also: Prandin side effects (in more detail)
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